2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N4178
    Isopropylidenylacetyl-marmesin 35178-20-2 98%
    Isopropylidenylacetyl-marmesin ((±)-Prantschimgin) is a coumarin isolated from the roots of F. bracteata.
    Isopropylidenylacetyl-marmesin
  • HY-N4186
    Glabrolide 10401-33-9 98%
    Glabrolide, derived from Glycyrrhiza uralensis Fisch., is a β-secretase 1 (BACE-1) inhibitor[1].
    Glabrolide
  • HY-N4190
    Britannilactone diacetate 1286694-67-4 98%
    Britannilactone diacetate (1,6-O,O-Diacetylbritannilactone; Compound 2) exhibits potential NO inhibition effect. Britannilactone diacetate exhibits activity against NO production induced by LPS in BV-2 microglial cells with the EC50 value of 6.3 μM. Britannilactone diacetate exhibits a favorable blood-brain barriers (BBB) penetration and absorption, distribution, metabolism, excretion, and toxicity (ADMET) property.
    Britannilactone diacetate
  • HY-N4219
    Saikosaponin B3 58316-42-0 99.54%
    Saikosaponin B3 is a saikosaponin isolated from the roots of Bupleurum falcatum L., with analgesic effect. Saikosaponin B3 inhibits ACTH-induced lipolysis in the fat cells.
    Saikosaponin B3
  • HY-N4291
    1,7-Dihydroxy-2,3-methylenedioxyxanthone 183210-63-1 98%
    1,7-Dihydroxy-2,3-methylenedioxyxanthone is found in Polygala cyparissias which is a small herb found in Brazil, Argentina and Uruguay.
    1,7-Dihydroxy-2,3-methylenedioxyxanthone
  • HY-N4295
    Bacopaside V 620592-16-7 98%
    Bacopaside V is a bioactive triterpenoid glycoside of Bacopa monniera, a herb having confirmed nervine tonic activity.
    Bacopaside V
  • HY-N5089
    (+)-Balanophonin 215319-47-4 98%
    (+)-Balanophonin is a phenolic compound that could be isolated from Passiflora edulis. (+)-Balanophonin possesses anti-oxidant, anticholinesterase, anti-inflammatory, anticancer, and antineurodegenerative activities.
    (+)-Balanophonin
  • HY-N5126
    Juncusol 62023-90-9 98%
    Juncusol, a phenanthrenoid found in Juncus setchuenensis, possesses anxiolytic effect. Juncusol is associated with metabolic changes in cortical serotonin/dopamine levels in Mice.
    Juncusol
  • HY-N5159
    Ampullosporin A 197960-94-4 98%
    Ampullosporin A is a peptaibol-type polypeptide that can be isolated from the fungus Sepedonium ampullosporum HKI-0053, exhibiting neuroleptic-like activity. Ampullosporin A can inhibit hyperactivity induced by NMDA receptor antagonist MK-801 (HY-15084B) and ameliorate social behavior abnormalities caused by subchronic drug treatment. Ampullosporin A alters the activity of glutamate receptors without affecting dopamine D1 and D2 receptors.
    Ampullosporin A
  • HY-N6032
    Esculentoside B 60820-94-2 98%
    Esculentoside B (Phytolaccoside B) is a natural product from the roots of Phytolacca acinosa Roxb. Esculentoside B is neurotoxic to zebrafish larvae, and impairs their central nervous system development. Esculentoside B inhibits inflammatory response and has antifungal activity.
    Esculentoside B
  • HY-N6097
    Amauromine 88360-87-6 98%
    Amauromine is a peripheral selective cannabinoid receptor type 1 (CB1) receptor antagonist with Ki and Kb values of 178 nM and 66.6 nM, respectively.
    Amauromine
  • HY-N6619
    Lycoramine hydrobromide 89505-76-0 98%
    Lycoramine hydrobromide, a dihydro-derivative of galanthamine, is isolated from Lycoris radiate. Lycoramine hydrobromide is a potent acetylcholinesterase (AChE) inhibitor.
    Lycoramine hydrobromide
  • HY-N6730
    Hydrolyzed Fumonisin B1 145040-09-1 98%
    Hydrolyzed Fumonisin B1 (Aminopentol) is the backbone and main hydrolysis product of the mycotoxin Fumonisin B1 (HY-N6719). Hydrolyzed Fumonisin B1 can weakly inhibit ceramide synthase.
    Hydrolyzed Fumonisin B1
  • HY-N7002
    Nagarine 41849-35-8 98%
    Nagarine, an alkaloid isolated from the roots of Aconitum nagarum Stapf (Ranunculaceae), is used to treat Rheumatic and neuralgic disorders.
    Nagarine
  • HY-N7013
    Hydroxy-Epsilon-Sanshool 252193-26-3 98%
    Hydroxy-Epsilon-Sanshool is an alkylamide isolated from Zanthoxylum bungeanum. Hydroxy-Epsilon-Sanshool produces key tingling and numbing chemosensates, and its content is important in determinant the pungency intensity of Zanthoxylum bungeanum.
    Hydroxy-Epsilon-Sanshool
  • HY-N7014
    Hydroxyl-​γ-​isosanshool 127514-62-9 98%
    Hydroxyl-γ-isosanshool is one of the major alkylamides in Z. bungeanum and Z. schinifolium oils. Hydroxyl-γ-isosanshoo induces a numbing sensation.
    Hydroxyl-​γ-​isosanshool
  • HY-N7044
    Vitexin arginine 98%
    Vitexin arginine is a c-glycosylated flavone, and is found in various medicinal plants species such as Ficus deltoid and Spirodela polyrhiza. Vitexin arginine has a wide range of pharmacological effects, including anti-oxidant, anti-cancer, anti-inflammatory, anti-hyperalgesic, and neuroprotective effects.
    Vitexin arginine
  • HY-N7214
    Termitomycamide E 1177258-62-6 98%
    Termitomycamide E is a fatty acid amide that can suppress endoplasmic reticulum stress. Termitomycamide E shows significant protective activity against T. titanicus-toxicity.
    Termitomycamide E
  • HY-N7265
    Epi-galantamine 1668-85-5 98%
    Epi-galantamine is a diastereomer of Galantamine. Epi-galantamine is an alkaloid isolated from the bulbs and flowers of Caucasian snowdrop (Galanthus woronowii). Epi-galantamine inhibits AChE with an EC50 of 45.7 μM.
    Epi-galantamine
  • HY-N7284
    Traxillaside 149415-62-3 98%
    Traxillaside is a plant-derived lignan with neuroprotective properties.
    Traxillaside
Cat. No. Product Name / Synonyms Application Reactivity